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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:
1. Administration of a marketed drug to a patient for an off-label indication without approval from a local IRB is permissible in which of the following situations?
A) The patient's physician considers that the risk/benefit ratio favors the use of the drug.
B) The drug is administered under a protocol sponsored by an NIH grant.
C) The drug is administered on the request of the patient or the patient's representative.
D) The patient's physician has filed a Notice of Claimed Investigational Exemption for a New Drug with the FDA.
2. From ethical and scientific validity standpoints, in addition to double blinding, which of the following research designs is best for determining a new medication's relative efficacy in treating acute stroke?
A) Placebo-controlled, randomized, parallel design
B) Crossover design comparing the new therapy with the best standard therapy
C) Placebo-controlled, crossover design
D) Parallel design comparing the new therapy with the best standard therapy
3. The prophylaxis of postsurgical deep vein thrombosis was reviewed in an article published 5 years ago. A researcher wishes to identify any studies since then that have used this article as a reference. What is the most appropriate database for this search?
A) International Pharmaceutical Abstracts
B) The Cochrane Collaboration
C) Science Citation Index
D) MEDLINE
4. A study compared treatment with cinacalcet versus treatment with placebo in subjects with known hyperparathyroidism. The primary outcome of the study was the proportion of study subjects with a mean intact parathyroid hormone level < 250 pg/mL. Among the cinacalcet group (n = 371), 43% of subjects achieved the primary outcome; among the placebo group (n =
370), 5% achieved the primary outcome (p<0.05).
Which of the following is the number needed to treat (NNT)?
A) 14
B) 3
C) 1
D) 8
5. A patient presents to the emergency department with a generalized rash. When questioned about recent changes in medication therapy, the patient reports starting glyburide 2 week ago.
Which of the following may be used to assess the causality between glyburide use and the patient's rash?
A) Naranjo Algorithm
B) Brief Medication Questionnaire
C) CAGE Questionnaire
D) Modified Morisky Scale
Solutions:
Question # 1 Answer: A | Question # 2 Answer: B | Question # 3 Answer: D | Question # 4 Answer: B | Question # 5 Answer: B |